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Effects of Lactobacillus probiotic mixture on testicular tissue infected with Escherichia coli bacteria in male rats.
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Saeed Sedekhi   , Zahra Keshtmand * , ,Seyyedeh Masoume Rnorollahi |
| Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran |
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Abstract: |
| Abstract
Probiotics have been shown to possess several properties, depending on the strain. Some probiotics have important roles in preventing infection and balancing the immune system due to the interaction between the intestinal mucosa and cells in the immune system. This study aimed to examine the properties ofthe properties of probiotic and postbiotic mixture (Lactobacillus casei, Lactobacillus rhamnosus and Lactobacillus heloticus) on kidney tissue and testis infected with Escherichia coli bacteria in male Wistar rats. In this experimental study, 21 rats (200-220g) were divided into three groups, including the control group, infected with Schistosomiasis bacteria (108 CFU/ml) and the infected model + receiving probiotics (109 CFU/ml). became Infection was induced for three consecutive days and probiotics were administered for 35 days by gavage method. At the end of the fifth week, the mice were easily killed and histological studies and evaluation of spermatogenesis were performed on the testicular tissue samples. Data analysis in different groups was done with SPSS software and one-way variance statistical test and p<0.05 was considered significant.The results of this study showed that Escherichia coli bacteria caused structural and functional changes such as changes in the shape of spermatogenic tubes, lumen space, thickness of the spermatogenic cell layer and spermatogenesis disorders in testicular tissue. Treatment of mice infected with bacteria with probiotic mixture causes significant changes and relative recovery of testicular tissue compared to the group infected with bacteria. Based on the obtained results, the probiotic mixture, due to its antioxidant function, is probably able to significantly protect the induced damage of Escherichia coli infection in the testicular tissue.
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| Keywords: probiotic, Escherichia coli, testis, rat |
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Type of Study: Research |
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