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Estrogen-gut microbiota axis and estrobolome in endometriosis: A review study
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Niloofar Taghipour   , Mahsa Nikjoo , Mobina Mohammadi , Mahsa Aghabozorg , Elaheh Salmeh , Erfan Soroush , Akram Sadat Tabatabaee Bafroee , Seyed Davar Siadat * |
| Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran |
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Abstract: |
Endometriosis, a common disease in women, ranks second only to all types of cancer. It significantly impacts women's overall health and reproductive health, with statistics indicating that one in every 10 women worldwide battles this condition. Endometriosis has various causes, including retrograde menstruation, immune system disorders, hormonal imbalances, surgical complications, and genetic factors. Traditional treatments for endometriosis have included non-steroidal anti-inflammatory drugs (NSAIDs), hormone therapy, and surgery, each with varying success rates and effectiveness. Recently, there has been discussion about the potential role of probiotics and estrobolome in addressing endometriosis through the estrogen-gut microbiota axis. An imbalance in gut microbiota can lead to an increase in beta-glucuronidase, which hinders the binding of estrogen and glucuronic acid, resulting in elevated circulating estrogen levels through enterohepatic circulation. This significantly contributes to the growth of abnormal lesions in endometriosis. Consequently, patients with endometriosis have a higher number of beta-glucuronidase-producing bacteria in their gut microbiota. Furthermore, research indicates that probiotics not only have the potential to inhibit the progression of endometriosis but are also effective in alleviating associated pain.
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| Keywords: Endometriosis, estrogen, microbiota, estrogen-gut microbiota axis |
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Type of Study: Review |
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