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The role of gut microbiota and adipocytokines in diabetes
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Masoumeh Nezhadali *   , Elham Ghorban |
| Assistant Professor, Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran. |
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Abstract: |
| The global prevalence of obesity has increased dramatically in recent decades. The prevalence of Type 2 diabetes is increasing worldwide in line with the growing obesity epidemic and is expected to have devastating consequences in the coming years. Adipose tissue synthesizes and secretes several bioactive peptides called adipocytokines, which play a role in regulating metabolism, obesity, and diabetes. Gut microbiota is another factor that is effective in sugar and fat metabolism and interacts with adipocytokines. The aim of the present study was to investigate the association of adipocytokines and gut microbiota with diabetes. In the present study, a comprehensive search was conducted in PubMed, Science Direct, and Google Scholar databases with the keywords Diabetes, Microbiota, Adipocytokines for articles published from 2010 to 2025. The results showed that the levels of adipocytokines and microbiota are associated with type 2 diabetes and insulin resistance, adiponectin levels are decreased in patients with T2D(Type 2 diabetes) and leptin resistin, TNF-α, interleukin-6 levels are increased. Based on evidence, adipocytokines and gut microbiota can be used as a biomarker for the prediction and treatment of T2D. |
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| Keywords: Adipocytokine, Type 2 diabetes, Gestational diabetes, Microbiota |
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Type of Study: Review |
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