|
Effects of adipokines and probiotics on non-alcoholic fatty liver disease
|
Mahdieh Jagirvand   , Masoumeh Nezhadali * |
| Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran |
|
|
Abstract: |
vThe prevalence of obesity and its complications, including deaths, are increasing worldwide. obesity is one of the most important causes of non- alcoholic fatty liver disease. This disease is the most common liver disorder caused by excessive deposition of fatty acids and triglycerides. In fatt tissue, a number of proteins called adipokines are secreted, which have different pro- inflammatory or anti – inflammatory effects. Adipokines play an important role in chronic or acute liver diseases. Studies have shown that adipokines play a role in the pathogenesis of NAFLD and its progression to NASH. Probiotics are microorganisms that can increase the number of beneficial gut bacteria and improve fat metabolism. Probiotics reduce the level of liver enzymes (aspartate aminotransferase, alanine aminotransferase and gamma glutamyl transferase) and inflammatory factors such as TNF-α, IL-6 and improve liver function. The results show that probiotics and adipokines can be used in the diagnosis and treatment of non-alcoholic fatty liver disease.
|
|
| Keywords: Adipokines, Non-alcoholic fatty liver disease, Probiotics, Obesity |
|
|
|
|
Type of Study: Research |
|
|
|
|
|
|
