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Investigation of probiotic bacteria (lactic acid bacteria) in the treatment of liver diseases
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Mahnaz Mohammadi *   |
| Assistant Professor, Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Islamshahr, Iran |
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Abstract: |
Introduction: The present article investigates the therapeutic efficacy of probiotic bacteria (lactic acid bacteria) in the treatment of liver diseases. The investigation of lactic acid bacteria (LAB) isolated from camel milk and their effects on liver cells has attracted attention due to the potential therapeutic benefits of these microorganisms. Camel milk is rich in bioactive compounds including lactoferrin, lysozyme, and various peptides that exhibit antioxidant and anti-inflammatory effects. These components modulate oxidative stress and inflammation, both of which are critical in cancer progression. The anti-apoptotic effects of lactic acid bacteria in reducing cancer cell survival are significant. By inducing apoptosis through intrinsic pathways, these bacteria can effectively reduce cell viability in hepatocellular carcinoma models. Lactic acid bacteria from camel milk show promising anticancer activities against liver cancer.
Conclusion: Hydrolyzed proteins in camel milk showed the ability to counteract liver dysfunction and have antihypertensive, antioxidant and kidney and liver protective properties. . Also, the antioxidant activity of camel milk can be attributed to its high content of vitamin C and its specific proteins that reduce reactive oxygen species (ROS) and thus protect cells from oxidative damage. Modulation of apoptosis pathways by lactic acid bacteria suggests their potential as adjuvant therapies alongside conventional treatments for liver cancer. |
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| Keywords: Lactic acid bacteria, antioxidant properties, liver dysfunction, hepatocellular |
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Type of Study: Review |
Subject:
General
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