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Antioxidant effects of nanochitosan-coated probiotic mixture in brain tissue of rats exposed to Aluminum chloride
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Aigin Kavoosi   , Zahra Keshtmand * |
| Department of Biology, CT.C., Islamic Azad University, Tehran, Iran |
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Abstract: |
| Aluminum is a toxic metal that is widely distributed in the environment and widely used in daily life. Probiotics, with their activity in the intestine, can produce compounds that trap and absorb pollutants.The aim of this study was to investigate the effects of nanochitosan carrying a probiotic mixture on the antioxidant level of brain tissue in male rats exposed to aluminum chloride.In this experimental study, 28 adult male Wistar rats were divided into 4 groups of 7: control,receiving aluminum chloride(100mg/kg),nanochitosan(1ml),aluminum chloride+ probiotic mixture (109CFU/ml). Infection induction and probiotic mixture intake were performed by gavage.After the end of the treatment period and dissection of the animals, brain tissue was extracted to measure some oxidative stress indices in different groups. Data analysis was performed in different groups using SPSS software and one-way variance statistical test, and P<0.05 was considered significant.The results of this study showed that in the group receiving aluminum chloride,a significant increase in malondialdehyde and an decrease in superoxide dismutase, catalase, glutathione peroxidase, and total antioxidant capacity was shown compared to the control group (P<0.05),while in the group treated with probiotic-carrying nanochitosan, a significant decrease in malondialdehyde and an increase in superoxide dismutase, catalase, glutathione peroxidase, and total antioxidant capacity was shown Compared to the infected group, it was shown (P<0.05). According to the findings of this study, nanochitosan carrying the probiotic mixture can probably be used as one of the effective compounds and supplements to modulate the damage caused by the aluminum chloride pollutant due to its antioxidant effects |
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| Keywords: Oxidative Stress, Brain Tissue, Probiotics, Aluminum Chloride, Rat, Nanochitosan |
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Type of Study: Research |
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