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Effect of postbiotic mixture (Lactobacillus plantarum, Lactobacillus paracasei and Lactobacillus brevis) on oxidative stress markers of brain tissue of rat infected with Staphylococcus aureus
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Zohrasadat Seyedbagheri1   , ZAHRA Keshtmand * |
| Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran |
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Abstract: |
The aim of this study was to investigate the effect of a postbiotic mixture (Lactobacillus plantarum, Lactobacillus paracasei, and Lactobacillus brevis) on oxidative stress indices in the brain tissue of rats infected with Staphylococcus aureus.In this experimental study, 21 male Wistar rats were divided into three groups including control group, infected with Staphylococcus aureus (108 CFU/ml) and infected model + postbiotic recipient (109 CFU/ml. The postbiotic mixture was given to rat by gavage for 35 days. After the treatment period and dissection of the animals, brain tissue was extracted to examine the activity levels of total antioxidant, superoxide dismutase, glutathione peroxidase, catalase and malondialdehyde in different groups. Data analysis was performed in different groups with SPSS software and one-way variance statistical test and P<0.05 was considered significant. The results showed a significant change in the levels of total antioxidant, superoxide dismutase, glutathione peroxidase, catalase and malondialdehyde in the infected groups compared to the control group ( P<0.05). While a significant decrease in malondialdehyde levels and an increase in total antioxidant levels, superoxide dismutase, glutathione peroxidase, and catalase were observed in the treatment groups compared to the infected group. (P<0.05). Based on the results obtained, the postbiotic mixture (Lactobacillus plantarum, Lactobacillus paracasei and Lactobacillus brevis) showed a modulating effect on the activity of oxidative stress markers in the brain tissue of rat infected with the bacteria. Therefore, it can probably be used as a promising therapeutic strategy.
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| Keywords: Postbiotic, Oxidative Stress, Brain, Staphylococcus aureus, Rat |
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Type of Study: Research |
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