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The Effect of Pineapple Extract on TNF-α Concentration in Liver Tissues of Melanoma-Induced Mice
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Foad Asjodi   , Hossein abed Abed natanzi * , Bahram Abedi , Aabednatanzi Gholami |
| Department of physical education and sport science, Science and research branch, Islamic Azad University, Tehran, Iran. |
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Abstract: |
Abstract:
Melanoma is the most aggressive subtype of skin cancer with high invasive potential and rapid metastasis to other organs. Recently, the role of physical exercise in the prevention and treatment of cancer has gained significant attention. Pineapple belongs to the Bromeliaceae family and the Bromelioideae subfamily, and its anti-cancer properties have been discussed. TNF-α operates through the NF-KB pathway, leading to an increase in Cyclin D1 expression. In many cases, TNF-α binding to Tumor Necrosis Factor Receptor 1 (TNFR1) activates the NF-KB transcription pathway, which leads to the inhabitation of apoptosis through upregulation of the cellular inhibitor of apoptosis protein 1(IAP1).
Therefore, the porpose of this study was to investigate the TNF-α concentration in liver tissues after pineapple extract consumption in melanoma-induced mice. This study was conducted on 16 C57 strain mice, divided into two groups: control and pineapple extract. After tumor induction in mice, a resistance training program and pineapple extract administration at a dose of 300 mg/kg were carried out through gavage for six weeks. After tissue sample collection, the TNF-α concentration in liver tissues was measured. The data were analyzed using one-way analysis of variance, and a significance level of p≤0.05 was considered. The findings demonstrated a significant reduction in TNF-α concentration in the pineapple group compared to the control group (p≤0.01).
This article has been extracted from the PhD thesis of Foad Asjadi and has been approved by the Ethics Committee of the Sport Science Research Institute (IR.SSRC.REC.1400.085). |
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| Keywords: Resistance Training, Pineapple, Melanoma, TNF-α |
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Type of Study: Research |
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