Protective effect of lactic acid postbiotic mixture on liver tissue infected with Salmonella typhimurium in male Wistar rats
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Zahra Keshtmand * , Leila Rad  |
Departmant of Biology,Central Tehran Branch, Islamic Azad Univercity, Tehran, Iran. |
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Abstract: |
The aim of this study was to investigate the protective effect of a postbiotic mixture (Lactobacillus plantarum, Lactobacillus paracasei, and Lactobacillus brevis) on the liver tissue of rats infected with Salmonella typhimurium.
In this experimental study, 21 male Wistar rats were divided into three groups including control group, infected with Salmonella Typhimurium CFU/ml (108) and infected model + postbiotic recipient (109 CFU/ml). Infection induction and postbiotic receipt were performed by gavage method. After the treatment period and dissection of the rats, liver tissue was extracted for histological examination in different groups. Then, different stages of tissue preparation were performed and histopathological sections were prepared with hematoxylin-eosin staining. Liver tissue of different groups was examined qualitatively and based on the severity of damage..
The results showed that significant changes in tissue damage were observed in the grooves infected with bacteria compared to the control. But these changes in the group treated with the postbiotic mixture, including the number of inflammatory cells, vacuolation, necrosis, hemorrhage, changes in the sinusoidal space, and liver lobule, were shown to be significant.
Based on the results obtained, the postbiotic mixture (Lactobacillus plantarum, Lactobacillus paracasei, and Lactobacillus brevis) showed an ameliorating effect on induced lesions in the liver tissue of rat infected with the bacteria. Therefore, it can probably be used as a protective and therapeutic strategy.
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Keywords: postbiotic, liver, Salmonella typhimurium, rat. |
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Type of Study: Research |
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